The article examines topical issues of how Ukrainian enterprises can enter international markets, as well as the methods they can use to successfully enter the market.Global markets bring great challenges, but also new opportunities in the context of globalization and competitive environment.This article examines various approaches to entering fore
Modeling Growth Kinetics, Interspecies Cell Fusion, and Metabolism of a Clostridium acetobutylicum/Clostridium ljungdahlii Syntrophic Coculture
ABSTRACT Clostridium acetobutylicum and Clostridium ljungdahlii grown in a syntrophic culture were recently shown to fuse membranes and exchange cytosolic contents, yielding hybrid cells with significant shifts in gene expression and growth phenotypes.Here, we introduce a dynamic genome-scale metabolic modeling framework to explore how cell fusion
Decoding Missense Variants by Incorporating Phase Separation via Machine Learning
Abstract Computational models have made significant progress in predicting the effect of protein variants.However, deciphering numerous variants of uncertain significance (VUS) located within intrinsically disordered regions (IDRs) remains challenging.To address this issue, we introduce Computer Stands phase separation, which is tightly linked to I
Therapeutic targeting of alternative splicing
Gene transcription leads to the generation of pre-mRNA molecules which contain both coding sequences (exons) and intervening non-coding sequences (introns).The primary transcript needs further processing which involves the excision of introns and ligation of exons.This process is called RNA splicing.Nearly all primary transcripts undergo alternativ